CATH Domain 5i8bA03

Level	CATH Code	Description
	2	Mainly Beta
	2.10	Ribbon
	2.10.110	Cysteine Rich Protein
	2.10.110.40	CREB-binding protein/p300 RING domain

Superfamily	2.10.110.40
Functional Family	E1A binding protein p300

2.3.1.48

Histone acetyltransferase.

based on mapping to UniProt Q92793

Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine.

-!- A group of enzymes acetylating histones. -!- Several of the enzymes can also acetylate lysines in other proteins.

CBP_HUMAN

Homo sapiens

CREB-binding protein

PDB	5I8B
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Fragment-Based Discovery of a Selective and Cell-Active Benzodiazepinone CBP/EP300 Bromodomain Inhibitor (CPI-637). Taylor, A.M., Cote, A., Hewitt, M.C., Pastor, R., Leblanc, Y., Nasveschuk, C.G., Romero, F.A., Crawford, T.D., Cantone, N., Jayaram, H., Setser, J., Murray, J., Beresini, M.H., de Leon Boenig, G., Chen, Z., Conery, A.R., Cummings, R.T., Dakin, L.A., Flynn, E.M., Huang, O.W., Kaufman, S., Keller, P.J., Kiefer, J.R., Lai, T., Li, Y., Liao, J., Liu, W., Lu, H., Pardo, E., Tsui, V., Wang, J., Wang, Y., Xu, Z., Yan, F., Yu, D., Zawadzke, L., Zhu, X., Zhu, X., Sims, R.J., Cochran, A.G., Bellon, S., Audia, J.E., Magnuson, S., Albrecht, B.K. Acs Med.Chem.Lett.