CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.30 | Glutaredoxin |
|
3.40.30.10 | Glutaredoxin |
Domain Context
CATH Clusters
| Superfamily | Glutaredoxin |
| Functional Family | Glutathione peroxidase |
Enzyme Information
| 1.11.1.12 |
Phospholipid-hydroperoxide glutathione peroxidase.
based on mapping to UniProt P36969
2 glutathione + a hydroperoxy-fatty-acyl-[lipid] = glutathione disulfide + a hydroxy-fatty-acyl-[lipid] + H(2)O.
-!- The products of action of EC 1.13.11.12 on phospholipids can act as acceptor; H(2)O(2) can also act, but much more slowly (cf. EC 1.11.1.9).
|
UniProtKB Entries (1)
| P36969 |
GPX4_HUMAN
Homo sapiens
Phospholipid hydroperoxide glutathione peroxidase
|
PDB Structure
| PDB | 5H5S |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Discovery of GPX4 inhibitory peptides from random peptide T7 phage display and subsequent structural analysis
Biochem. Biophys. Res. Commun.
|