CATH Domain 5fv2V00

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.10	Ribbon
	2.10.90	Cystine Knot Cytokines, subunit B
	2.10.90.10	Cystine-knot cytokines

Domain Context

CATH Clusters

Superfamily	Cystine-knot cytokines
Functional Family	Vascular endothelial growth factor A

Enzyme Information

UniProtKB Entries (1)

VEGFA_HUMAN

Homo sapiens

Vascular endothelial growth factor A

PDB Structure

PDB	5FV2
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Novel Interaction Mechanism of a Domain Antibody Based Inhibitor of Human Vascular Endothelial Growth Factor with Greater Potency Than Ranibizumab and Bevacizumab and Improved Capacity Over Aflibercept. Walker, A., Chung, C., Neu, M., Burman, M., Batuwangala, T., Jones, G., Tang, C., Steward, M., Mullin, M., Tournier, N., Lewis, A., Korczynska, J., Chung, V., Catchpole, I. J.Biol.Chem.