CATH Domain 5fdpA01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.200	Phosphorylase Kinase; domain 1
	3.30.200.20	Phosphorylase Kinase; domain 1

Domain Context

CATH Clusters

Superfamily	Phosphorylase Kinase; domain 1
Functional Family	Epithelial discoidin domain-containing receptor 1

Enzyme Information

2.7.10.1

Receptor protein-tyrosine kinase.

based on mapping to UniProt Q08345

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

Q08345

DDR1_HUMAN

Homo sapiens

Epithelial discoidin domain-containing receptor 1

PDB Structure

PDB	5FDP
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structure-Based Design of Tetrahydroisoquinoline-7-carboxamides as Selective Discoidin Domain Receptor 1 (DDR1) Inhibitors. Wang, Z., Bian, H., Bartual, S.G., Du, W., Luo, J., Zhao, H., Zhang, S., Mo, C., Zhou, Y., Xu, Y., Tu, Z., Ren, X., Lu, X., Brekken, R.A., Yao, L., Bullock, A.N., Su, J., Ding, K. J.Med.Chem.