CATH Domain 5arfA03

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.25	Alpha Horseshoe
	1.25.40	Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat
	1.25.40.10	Tetratricopeptide repeat domain

Domain Context

CATH Clusters

Superfamily	Tetratricopeptide repeat domain
Functional Family	N-lysine methyltransferase SMYD2 isoform X2

Enzyme Information

2.1.1.-	Methyltransferases. based on mapping to UniProt Q9NRG4
2.1.1.43	Histone-lysine N-methyltransferase. based on mapping to UniProt Q9NRG4 S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

UniProtKB Entries (1)

SMYD2_HUMAN

Homo sapiens

N-lysine methyltransferase SMYD2

PDB Structure

PDB	5ARF
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery and Characterization of a Highly Potent and Selective Aminopyrazoline-Based in Vivo Probe (Bay-598) for the Protein Lysine Methyltransferase Smyd2. Eggert, E., Hillig, R.C., Kohr, S., Stockigt, D., Weiske, J., Barak, N., Mowat, J., Brumby, T., Christ, C.D., Ter Laak, A., Lang, T., Fernandez-Montalvan, A.E., Badock, V., Weinmann, H., Hartung, I.V., Barsyte-Lovejoy, D., Szewczyk, M., Kennedy, S., Li, F., Vedadi, M., Brown, P.J., Santhakumar, V., Arrowsmith, C.H., Stellfeld, T., Stresemann, C. J.Med.Chem.