CATH Classification

Domain Context

CATH Clusters

Superfamily P-loop containing nucleotide triphosphate hydrolases
Functional Family ATP-dependent RNA helicase DDX6

Enzyme Information

3.6.4.13
RNA helicase.
based on mapping to UniProt P26196
ATP + H(2)O = ADP + phosphate.
-!- RNA helicases utilize the energy from ATP hydrolysis to unwind RNA. -!- Some of them unwind RNA with a 3' to 5' polarity, other show 5' to 3' polarity. -!- Some helicases unwind DNA as well as RNA. -!- May be identical with EC 3.6.4.12 (DNA helicase).

UniProtKB Entries (1)

A5YKK6
CNOT1_HUMAN
Homo sapiens
CCR4-NOT transcription complex subunit 1

PDB Structure

PDB 5ANR
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure of a Human 4E-T/Ddx6/Cnot1 Complex Reveals the Different Interplay of Ddx6-Binding Proteins with the Ccr4-not Complex.
Ozgur, S., Basquin, J., Kamenska, A., Filipowicz, W., Standart, N., Conti, E.
Cell Rep.