CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.170 | Formyl transferase, N-terminal domain |
Domain Context
CATH Clusters
| Superfamily | Formyl transferase, N-terminal domain |
| Functional Family | Trifunctional purine biosynthetic protein adenosine-3 |
Enzyme Information
| 2.1.2.2 |
Phosphoribosylglycinamide formyltransferase.
based on mapping to UniProt P22102
10-formyltetrahydrofolate + N(1)-(5-phospho-D-ribosyl)glycinamide = tetrahydrofolate + N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide.
|
| 6.3.4.13 |
Phosphoribosylamine--glycine ligase.
based on mapping to UniProt P22102
ATP + 5-phospho-D-ribosylamine + glycine = ADP + phosphate + N(1)- (5-phospho-D-ribosyl)glycinamide.
-!- Formerly EC 6.3.1.3.
|
| 6.3.3.1 |
Phosphoribosylformylglycinamidine cyclo-ligase.
based on mapping to UniProt P22102
ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.
|
UniProtKB Entries (1)
| P22102 |
PUR2_HUMAN
Homo sapiens
Trifunctional purine biosynthetic protein adenosine-3
|
PDB Structure
| PDB | 4ZZ1 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Regioisomers as Targeted Antifolates for Folate Receptor alpha and the Proton-Coupled Folate Transporter in Human Tumors.
J.Med.Chem.
|
