1 keywords

CATH Domain 4zvvD02

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.90 Alpha-Beta Complex
Topology 3.90.110 L-2-Hydroxyisocaproate Dehydrogenase; Chain A, domain 2
Homologous Superfamily 3.90.110.10 Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal

Domain Context

CATH Clusters

Superfamily Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal
Functional Family L-lactate dehydrogenase A chain

Enzyme Information

1.1.1.27
L-lactate dehydrogenase.
based on mapping to UniProt P00338
(S)-lactate + NAD(+) = pyruvate + NADH.
-!- Also oxidizes other (S)-2-hydroxymonocarboxylic acids. -!- NADP(+) acts, more slowly, with the animal, but not the bacterial, enzyme.

UniProtKB Entries (1)

P00338
LDHA_HUMAN
Homo sapiens
L-lactate dehydrogenase A chain

PDB Structure

PDB 4ZVV
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Metabolic plasticity underpins innate and acquired resistance to LDHA inhibition.
Boudreau, A., Purkey, H.E., Hitz, A., Robarge, K., Peterson, D., Labadie, S., Kwong, M., Hong, R., Gao, M., Del Nagro, C., Pusapati, R., Ma, S., Salphati, L., Pang, J., Zhou, A., Lai, T., Li, Y., Chen, Z., Wei, B., Yen, I., Sideris, S., McCleland, M., Firestein, R., Corson, L., Vanderbilt, A., Williams, S., Daemen, A., Belvin, M., Eigenbrot, C., Jackson, P.K., Malek, S., Hatzivassiliou, G., Sampath, D., Evangelista, M., O'Brien, T.
Nat.Chem.Biol.