CATH Domain 4zk5B01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.200	Phosphorylase Kinase; domain 1
	3.30.200.20	Phosphorylase Kinase; domain 1

Domain Context

CATH Clusters

Superfamily	Phosphorylase Kinase; domain 1
Functional Family	Mitogen-activated protein kinase kinase kinase kinase 4

Enzyme Information

2.7.11.1

Non-specific serine/threonine protein kinase.

based on mapping to UniProt O95819

ATP + a protein = ADP + a phosphoprotein.

-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

O95819

M4K4_HUMAN

Homo sapiens

Mitogen-activated protein kinase kinase kinase kinase 4

PDB Structure

PDB	4ZK5
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structure-Based Design of GNE-495, a Potent and Selective MAP4K4 Inhibitor with Efficacy in Retinal Angiogenesis. Ndubaku, C.O., Crawford, T.D., Chen, H., Boggs, J.W., Drobnick, J., Harris, S.F., Jesudason, R., McNamara, E., Nonomiya, J., Sambrone, A., Schmidt, S., Smyczek, T., Vitorino, P., Wang, L., Wu, P., Yeung, S., Chen, J., Chen, K., Ding, C.Z., Wang, T., Xu, Z., Gould, S.E., Murray, L.J., Ye, W. Acs Med.Chem.Lett.