CATH Classification
Level | CATH Code | Description |
---|---|---|
3 | Alpha Beta | |
3.40 | 3-Layer(aba) Sandwich | |
3.40.470 | Uracil-DNA Glycosylase, subunit E | |
3.40.470.10 | Uracil-DNA glycosylase-like domain |
Domain Context
CATH Clusters
Superfamily | Uracil-DNA glycosylase-like domain |
Functional Family | G/T mismatch-specific thymine DNA glycosylase |
Enzyme Information
3.2.2.29 |
Thymine-DNA glycosylase.
based on mapping to UniProt Q13569
Hydrolyzes mismatched double-stranded DNA and polynucleotides, releasing free thymine.
-!- Thymine-DNA glycosylase is part of the DNA-repair machinery. -!- Thymine removal is fastest when it is from a G/T mismatch with a 5'-flanking C/G pair. -!- The glycosylase removes uracil from G/U, C/U, and T/U base pairs faster than it removes thymine from G/T.
|
UniProtKB Entries (1)
Q13569 |
TDG_HUMAN
Homo sapiens
G/T mismatch-specific thymine DNA glycosylase
|
PDB Structure
PDB | 4Z3A |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Thymine DNA glycosylase exhibits negligible affinity for nucleobases that it removes from DNA.
Nucleic Acids Res.
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