CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.200 | Phosphorylase Kinase; domain 1 |
|
3.30.200.20 | Phosphorylase Kinase; domain 1 |
Domain Context
CATH Clusters
| Superfamily | Phosphorylase Kinase; domain 1 |
| Functional Family | Putative serine/threonine-protein kinase PLK4 |
Enzyme Information
| 2.7.11.21 |
Polo kinase.
based on mapping to UniProt O00444
ATP + a protein = ADP + a phosphoprotein.
-!- The enzyme associates with the spindle pole during mitosis and is thought to play an important role in the dynamic function of the mitotic spindle during chromosome segregation. -!- The human form of the enzyme, Plk1, does not phosphorylate histone H1, enolase and phosvitin but it can phosphorylate myelin basic protein and microtubule-associated protein MAP-2, although to a lesser extent than casein. -!- Formerly EC 2.7.1.37.
|
UniProtKB Entries (1)
| O00444 |
PLK4_HUMAN
Homo sapiens
Serine/threonine-protein kinase PLK4
|
PDB Structure
| PDB | 4YUR |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Cell biology. Reversible centriole depletion with an inhibitor of Polo-like kinase 4.
Science
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