CATH Domain 4yt6H01

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.40	Beta Barrel
	2.40.10	Thrombin, subunit H
	2.40.10.10	Trypsin-like serine proteases

Domain Context

CATH Clusters

Superfamily	Trypsin-like serine proteases
Functional Family

Enzyme Information

3.4.21.21

Coagulation factor VIIa.

based on mapping to UniProt P08709

Selective cleavage of Arg-|-Ile bond in factor X to form factor Xa.

-!- Formed from the precursor factor VII. -!- The cattle enzyme is more readily inhibited by diisopropyl fluorophosphate than the human. -!- Belongs to peptidase family S1.

UniProtKB Entries (1)

P08709

FA7_HUMAN

Homo sapiens

Coagulation factor VII

PDB Structure

PDB	4YT6
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Design and synthesis of potent, selective phenylimidazole-based FVIIa inhibitors. Glunz, P.W., Cheng, X., Cheney, D.L., Weigelt, C.A., Wei, A., Luettgen, J.M., Wong, P.C., Wexler, R.R., Priestley, E.S. Bioorg.Med.Chem.Lett.