CATH Domain 4xz1A03

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.505	SHC Adaptor Protein
	3.30.505.10	SH2 domain

Domain Context

CATH Clusters

Superfamily	SH2 domain
Functional Family	Tyrosine-protein kinase

Enzyme Information

2.7.10.2

Non-specific protein-tyrosine kinase.

based on mapping to UniProt P43403

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P43403

ZAP70_HUMAN

Homo sapiens

Tyrosine-protein kinase ZAP-70

PDB Structure

PDB	4XZ1
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Modification by covalent reaction or oxidation of cysteine residues in the tandem-SH2 domains of ZAP-70 and Syk can block phosphopeptide binding. Visperas, P.R., Winger, J.A., Horton, T.M., Shah, N.H., Aum, D.J., Tao, A., Barros, T., Yan, Q., Wilson, C.G., Arkin, M.R., Weiss, A., Kuriyan, J. Biochem. J.