CATH Domain 4xucA00

Superfamily	Vaccinia Virus protein VP39
Functional Family	Catechol O-methyltransferase

2.1.1.6

Catechol O-methyltransferase.

based on mapping to UniProt P21964

S-adenosyl-L-methionine + a catechol = S-adenosyl-L-homocysteine + a guaiacol.

-!- The mammalian enzymes act more rapidly on catecholamines such as adrenaline or noradrenaline than on catechols.

COMT_HUMAN

Homo sapiens

Catechol O-methyltransferase

PDB	4XUC
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Synthesis and Evaluation of Heterocyclic Catechol Mimics as Inhibitors of Catechol-O-methyltransferase (COMT). Harrison, S.T., Poslusney, M.S., Mulhearn, J.J., Zhao, Z., Kett, N.R., Schubert, J.W., Melamed, J.Y., Allison, T.J., Patel, S.B., Sanders, J.M., Sharma, S., Smith, R.F., Hall, D.L., Robinson, R.G., Sachs, N.A., Hutson, P.H., Wolkenberg, S.E., Barrow, J.C. Acs Med.Chem.Lett.