CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.300 | P-loop containing nucleotide triphosphate hydrolases |
Domain Context
CATH Clusters
| Superfamily | P-loop containing nucleotide triphosphate hydrolases |
| Functional Family | Cystic fibrosis transmembrane conductance regulator |
Enzyme Information
| 5.6.1.6 |
Channel-conductance-controlling ATPase.
based on mapping to UniProt P13569
ATP + H(2)O + closed Cl(-) channel = ADP + phosphate + open Cl(-) channel.
-!- ABC-type (ATP-binding cassette-type) ATPase, characterized by the presence of two similar ATP-binding domains. -!- The enzyme is found in animals, and in humans its absence brings about cystic fibrosis. -!- Unlike most of the ABC transporters, chloride pumping is not directly coupled to ATP hydrolysis. -!- Instead, the passive flow of anions through the channel is gated by cycles of ATP binding and hydrolysis by the ATP-binding domains. -!- The enzyme is also involved in the functioning of other transmembrane channels. -!- Formerly EC 3.6.3.49.
|
UniProtKB Entries (1)
| P13569 |
CFTR_HUMAN
Homo sapiens
Cystic fibrosis transmembrane conductance regulator
|
PDB Structure
| PDB | 4WZ6 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Binding screen for cystic fibrosis transmembrane conductance regulator correctors finds new chemical matter and yields insights into cystic fibrosis therapeutic strategy.
Protein Sci.
|
