CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.309 | Aldehyde Dehydrogenase; Chain A, domain 2 |
|
3.40.309.10 | Aldehyde Dehydrogenase; Chain A, domain 2 |
Domain Context
CATH Clusters
| Superfamily | Aldehyde Dehydrogenase; Chain A, domain 2 |
| Functional Family | Mitochondrial aldehyde dehydrogenase 2 |
Enzyme Information
| 1.2.1.36 |
Retinal dehydrogenase.
based on mapping to UniProt P00352
Retinal + NAD(+) + H(2)O = retinoate + NADH.
-!- Acts on both the 11-trans- and 13-cis-forms of retinal.
|
| 1.2.1.- |
With NAD(+) or NADP(+) as acceptor.
based on mapping to UniProt P00352
|
UniProtKB Entries (1)
| P00352 |
AL1A1_HUMAN
Homo sapiens
Retinal dehydrogenase 1
|
PDB Structure
| PDB | 4WPN |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Characterization of Two Distinct Structural Classes of Selective Aldehyde Dehydrogenase 1A1 Inhibitors.
J.Med.Chem.
|