CATH Domain 4q2vA01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.420	Ricin (A subunit); domain 1
	3.40.420.10	Ricin (A subunit), domain 1

Domain Context

CATH Clusters

Superfamily	Ricin (A subunit), domain 1
Functional Family	Ricin

Enzyme Information

3.2.2.22

rRNA N-glycosylase.

based on mapping to UniProt P02879

Endohydrolysis of the N-glycosidic bond at one specific adenosine on the 28S rRNA.

-!- Ricin A-chain and related toxins show this activity. -!- Naked rRNA is attacked more slowly than rRNA in intact ribosomes. -!- Naked rRNA from Escherichia coli is cleaved at a corresponding position.

UniProtKB Entries (1)

P02879

RICI_RICCO

Ricinus communis

Ricin

PDB Structure

PDB	4Q2V
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Baicalin inhibits the lethality of ricin in mice by inducing protein oligomerization. Dong, J., Zhang, Y., Chen, Y., Niu, X., Zhang, Y., Li, R., Yang, C., Wang, Q., Li, X., Deng, X. J.Biol.Chem.