1 keywords

CATH Domain 4oypA01

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.30 2-Layer Sandwich
Topology 3.30.70 Alpha-Beta Plaits
Homologous Superfamily 3.30.70.1230 Nucleotide cyclase

Domain Context

CATH Clusters

Superfamily Nucleotide cyclase
Functional Family Adenylate cyclase type 10

Enzyme Information

4.6.1.1
Adenylate cyclase.
based on mapping to UniProt Q96PN6
ATP = 3',5'-cyclic AMP + diphosphate.
-!- Also acts on dATP to form 3',5'-cyclic dAMP. -!- Requires pyruvate. -!- Activated by NAD(+) in presence of EC 2.4.2.31.

UniProtKB Entries (1)

Q96PN6
ADCYA_HUMAN
Homo sapiens
Adenylate cyclase type 10

PDB Structure

PDB 4OYP
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure of human soluble adenylate cyclase reveals a distinct, highly flexible allosteric bicarbonate binding pocket.
Saalau-Bethell, S.M., Berdini, V., Cleasby, A., Congreve, M., Coyle, J.E., Lock, V., Murray, C.W., O'Brien, M.A., Rich, S.J., Sambrook, T., Vinkovic, M., Yon, J.R., Jhoti, H.
Chemmedchem