CATH Domain 4otpA02

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CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.510	Transferase(Phosphotransferase); domain 1
	1.10.510.10	Transferase(Phosphotransferase) domain 1

Domain Context

CATH Clusters

Superfamily	Transferase(Phosphotransferase) domain 1
Functional Family	Serine/threonine-protein kinase RIO1

Enzyme Information

3.6.3.-	Acting on acid anhydrides; catalyzing transmembrane movement of substances. based on mapping to UniProt Q9BRS2
2.7.11.1	Non-specific serine/threonine protein kinase. based on mapping to UniProt Q9BRS2 ATP + a protein = ADP + a phosphoprotein. -!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

RIOK1_HUMAN

Homo sapiens

Serine/threonine-protein kinase RIO1

PDB Structure

PDB	4OTP
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Dominant Rio1 kinase/ATPase catalytic mutant induces trapping of late pre-40S biogenesis factors in 80S-like ribosomes. Ferreira-Cerca, S., Kiburu, I., Thomson, E., LaRonde, N., Hurt, E. Nucleic Acids Res.