CATH Domain 4o3tB02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.1680	ligand-binding face of the semaphorins, domain 2
	3.30.1680.10	ligand-binding face of the semaphorins, domain 2

Domain Context

CATH Clusters

Superfamily	ligand-binding face of the semaphorins, domain 2
Functional Family	Macrophage-stimulating 1 receptor b

Enzyme Information

2.7.10.1

Receptor protein-tyrosine kinase.

based on mapping to UniProt P08581

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P14210

HGF_HUMAN

Homo sapiens

Hepatocyte growth factor

PDB Structure

PDB	4O3T
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	An allosteric switch for pro-HGF/Met signaling using zymogen activator peptides. Landgraf, K.E., Steffek, M., Quan, C., Tom, J., Yu, C., Santell, L., Maun, H.R., Eigenbrot, C., Lazarus, R.A. Nat.Chem.Biol.