CATH Domain 4o2rB00

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CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.300	P-loop containing nucleotide triphosphate hydrolases

Domain Context

CATH Clusters

Superfamily	P-loop containing nucleotide triphosphate hydrolases
Functional Family	GTP-binding protein Rheb homolog

Enzyme Information

UniProtKB Entries (1)

RHEB_MOUSE

Mus musculus

GTP-binding protein Rheb

PDB Structure

PDB	4O2R
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structure-guided mutation of the conserved G3-box glycine in Rheb generates a constitutively activated regulator of mammalian target of rapamycin (mTOR). Mazhab-Jafari, M.T., Marshall, C.B., Ho, J., Ishiyama, N., Stambolic, V., Ikura, M. J.Biol.Chem.