CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.60 | Sandwich |
|
2.60.60 | Lipoxygenase-1 |
|
2.60.60.20 | PLAT/LH2 domain |
Domain Context
CATH Clusters
| Superfamily | PLAT/LH2 domain |
| Functional Family | Arachidonate 5-lipoxygenase a |
Enzyme Information
| 1.13.11.33 |
Arachidonate 15-lipoxygenase.
based on mapping to UniProt O15296
Arachidonate + O(2) = (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa- 5,8,11,13-tetraenoate.
-!- The product is rapidly converted to the corresponding 15S-hydroxy compound.
|
| 1.13.11.- |
With incorporation of two atoms of oxygen.
based on mapping to UniProt O15296
|
UniProtKB Entries (1)
| O15296 |
LX15B_HUMAN
Homo sapiens
Arachidonate 15-lipoxygenase B
|
PDB Structure
| PDB | 4NRE |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
The structure of human 15-lipoxygenase-2 with a substrate mimic.
J.Biol.Chem.
|
