CATH Classification

Domain Context

CATH Clusters

Superfamily Tumor Necrosis Factor Receptor, subunit A, domain 2
Functional Family Ephrin type-A receptor 5

Enzyme Information

2.7.10.1
Receptor protein-tyrosine kinase.
based on mapping to UniProt P54764
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P52803
EFNA5_HUMAN
Homo sapiens
Ephrin-A5

PDB Structure

PDB 4M4R
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Insights into Eph receptor tyrosine kinase activation from crystal structures of the EphA4 ectodomain and its complex with ephrin-A5.
Xu, K., Tzvetkova-Robev, D., Xu, Y., Goldgur, Y., Chan, Y.P., Himanen, J.P., Nikolov, D.B.
Proc.Natl.Acad.Sci.USA