CATH Classification
Level | CATH Code | Description |
---|---|---|
2 | Mainly Beta | |
2.10 | Ribbon | |
2.10.50 | Tumor Necrosis Factor Receptor, subunit A; domain 2 | |
2.10.50.10 | Tumor Necrosis Factor Receptor, subunit A, domain 2 |
Domain Context
CATH Clusters
Superfamily | Tumor Necrosis Factor Receptor, subunit A, domain 2 |
Functional Family | Ephrin type-A receptor 5 |
Enzyme Information
2.7.10.1 |
Receptor protein-tyrosine kinase.
based on mapping to UniProt P54764
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.
|
UniProtKB Entries (1)
P52803 |
EFNA5_HUMAN
Homo sapiens
Ephrin-A5
|
PDB Structure
PDB | 4M4R |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Insights into Eph receptor tyrosine kinase activation from crystal structures of the EphA4 ectodomain and its complex with ephrin-A5.
Proc.Natl.Acad.Sci.USA
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