CATH Domain 4loyH02

Level	CATH Code	Description
	2	Mainly Beta
	2.40	Beta Barrel
	2.40.10	Thrombin, subunit H
	2.40.10.10	Trypsin-like serine proteases

Superfamily	Trypsin-like serine proteases
Functional Family	Prothrombin

3.4.21.5

Thrombin.

based on mapping to UniProt P00734

Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.

-!- More selective than trypsin and plasmin. -!- Belongs to peptidase family S1. -!- Formerly EC 3.4.4.13.

P00734	THRB_HUMAN Homo sapiens Prothrombin
P09945	HIRV2_HIRME Hirudo medicinalis Hirudin variant-2

PDB	4LOY
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	5-Chlorothiophene-2-carboxylic acid [(S)-2-[2-methyl-3-(2-oxopyrrolidin-1-yl)benzenesulfonylamino]-3-(4-methylpiperazin-1-yl)-3-oxopropyl]amide (SAR107375), a selective and potent orally active dual thrombin and factor Xa inhibitor. Meneyrol, J., Follmann, M., Lassalle, G., Wehner, V., Barre, G., Rousseaux, T., Altenburger, J.M., Petit, F., Bocskei, Z., Schreuder, H., Alet, N., Herault, J.P., Millet, L., Dol, F., Florian, P., Schaeffer, P., Sadoun, F., Klieber, S., Briot, C., Bono, F., Herbert, J.M. J.Med.Chem.