CATH Domain 4lorA01

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.60	Sandwich
	2.60.120	Jelly Rolls
	2.60.120.290	Spermadhesin, CUB domain

Domain Context

CATH Clusters

Superfamily	Spermadhesin, CUB domain
Functional Family	complement C1s subcomponent

Enzyme Information

3.4.21.42

Complement subcomponent C1s.

based on mapping to UniProt P09871

Cleavage of Arg-|-Ala bond in complement component C4 to form C4a and C4b, and Lys(or Arg)-|-Lys bond in complement component C2 to form C2a and C2b: the 'classical' pathway C3 convertase.

-!- Activated from proenzyme C1s in plasma by the activated complement subcomponent C1r. -!- Belongs to peptidase family S1.

UniProtKB Entries (1)

P09871

C1S_HUMAN

Homo sapiens

Complement C1s subcomponent

PDB Structure

PDB	4LOR
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structural basis of the C1q/C1s interaction and its central role in assembly of the C1 complex of complement activation. Venkatraman Girija, U., Gingras, A.R., Marshall, J.E., Panchal, R., Sheikh, M.A., Gal, P., Schwaeble, W.J., Mitchell, D.A., Moody, P.C., Wallis, R. Proc.Natl.Acad.Sci.USA