CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.300 | P-loop containing nucleotide triphosphate hydrolases |
Domain Context
CATH Clusters
| Superfamily | P-loop containing nucleotide triphosphate hydrolases |
| Functional Family | KRAS proto-oncogene, GTPase |
Enzyme Information
UniProtKB Entries (1)
| P01112 |
RASH_HUMAN
Homo sapiens
GTPase HRas
|
PDB Structure
| PDB | 4L9S |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions.
Nature
|
