CATH Domain 4kpwA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.572	Thymidylate Synthase; Chain A
	3.30.572.10	Thymidylate synthase/dCMP hydroxymethylase domain

Domain Context

CATH Clusters

Superfamily	Thymidylate synthase/dCMP hydroxymethylase domain
Functional Family	Possible thymidylate synthase

Enzyme Information

2.1.1.45

Thymidylate synthase.

based on mapping to UniProt P04818

5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.

UniProtKB Entries (1)

TYSY_HUMAN

Homo sapiens

Thymidylate synthase

PDB Structure

PDB	4KPW
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Hotspots in an obligate homodimeric anticancer target. Structural and functional effects of interfacial mutations in human thymidylate synthase. Salo-Ahen, O.M., Tochowicz, A., Pozzi, C., Cardinale, D., Ferrari, S., Boum, Y., Mangani, S., Stroud, R.M., Saxena, P., Myllykallio, H., Costi, M.P., Ponterini, G., Wade, R.C. J.Med.Chem.