CATH Domain 4k4fA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.228	Phosphoenolpyruvate Carboxykinase; domain 3
	3.90.228.10

Domain Context

CATH Clusters

Superfamily	3.90.228.10
Functional Family	Poly [ADP-ribose] polymerase tankyrase-2

Enzyme Information

2.4.2.30

NAD(+) ADP-ribosyltransferase.

based on mapping to UniProt O95271

NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D- ribosyl)(n+1)-acceptor.

-!- The ADP-D-ribosyl group of NAD(+) is transferred to an acceptor carboxy group on a histone or the enzyme itself, and further ADP- ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units.

2.4.2.-

Pentosyltransferases.

based on mapping to UniProt O95271

UniProtKB Entries (1)

O95271

TNKS1_HUMAN

Homo sapiens

Poly [ADP-ribose] polymerase tankyrase-1

PDB Structure

PDB	4K4F
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery of novel, induced-pocket binding oxazolidinones as potent, selective, and orally bioavailable tankyrase inhibitors. Bregman, H., Chakka, N., Guzman-Perez, A., Gunaydin, H., Gu, Y., Huang, X., Berry, V., Liu, J., Teffera, Y., Huang, L., Egge, B., Mullady, E.L., Schneider, S., Andrews, P.S., Mishra, A., Newcomb, J., Serafino, R., Strathdee, C.A., Turci, S.M., Wilson, C., Dimauro, E.F. J.Med.Chem.