CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.20 | Up-down Bundle |
|
1.20.80 | Acyl-CoA Binding Protein |
|
1.20.80.40 | Prp8 RNase H domain, fingers region |
Domain Context
CATH Clusters
| Superfamily | 1.20.80.40 |
| Functional Family |
Enzyme Information
UniProtKB Entries (1)
| Q6P2Q9 |
PRP8_HUMAN
Homo sapiens
Pre-mRNA-processing-splicing factor 8
|
PDB Structure
| PDB | 4JK8 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
A conformational switch in PRP8 mediates metal ion coordination that promotes pre-mRNA exon ligation.
Nat.Struct.Mol.Biol.
|