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1 keywords

CATH Domain 4j51B00

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.90 Alpha-Beta Complex
Topology 3.90.190 Protein-Tyrosine Phosphatase; Chain A
Homologous Superfamily 3.90.190.10 Protein tyrosine phosphatase superfamily

Domain Context

CATH Clusters

Superfamily Protein tyrosine phosphatase superfamily
Functional Family Tyrosine-protein phosphatase non-receptor type 12

Enzyme Information

3.1.3.48
Protein-tyrosine-phosphatase.
based on mapping to UniProt Q9Y2R2
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
-!- Dephosphorylates O-phosphotyrosine groups in phosphoproteins, such as the products of EC 2.7.10.2.

UniProtKB Entries (1)

Q9Y2R2
PTN22_HUMAN
Homo sapiens
Tyrosine-protein phosphatase non-receptor type 22

PDB Structure

PDB 4J51
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
A Potent and Selective Small-Molecule Inhibitor for the Lymphoid-Specific Tyrosine Phosphatase (LYP), a Target Associated with Autoimmune Diseases.
He, Y., Liu, S., Menon, A., Stanford, S., Oppong, E., Gunawan, A.M., Wu, L., Wu, D.J., Barrios, A.M., Bottini, N., Cato, A.C., Zhang, Z.Y.
J.Med.Chem.
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