CATH Domain 4j23A02

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.60	Sandwich
	2.60.40	Immunoglobulin-like
	2.60.40.10	Immunoglobulins

Domain Context

CATH Clusters

Superfamily	Immunoglobulins
Functional Family	Fibroblast growth factor receptor

Enzyme Information

2.7.10.1

Receptor protein-tyrosine kinase.

based on mapping to UniProt P21802

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P21802

FGFR2_HUMAN

Homo sapiens

Fibroblast growth factor receptor 2

PDB Structure

PDB	4J23
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Molecular mechanism of SSR128129E, an extracellularly acting, small-molecule, allosteric inhibitor of FGF receptor signaling. Herbert, C., Schieborr, U., Saxena, K., Juraszek, J., De Smet, F., Alcouffe, C., Bianciotto, M., Saladino, G., Sibrac, D., Kudlinzki, D., Sreeramulu, S., Brown, A., Rigon, P., Herault, J.P., Lassalle, G., Blundell, T.L., Rousseau, F., Gils, A., Schymkowitz, J., Tompa, P., Herbert, J.M., Carmeliet, P., Gervasio, F.L., Schwalbe, H., Bono, F. Cancer Cell