CATH Domain 4isiL00

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.10	Ribbon
	2.10.25	Laminin
	2.10.25.10	Laminin

Domain Context

CATH Clusters

Superfamily	Laminin
Functional Family	Coagulation factor VII

Enzyme Information

3.4.21.21

Coagulation factor VIIa.

based on mapping to UniProt P08709

Selective cleavage of Arg-|-Ile bond in factor X to form factor Xa.

-!- Formed from the precursor factor VII. -!- The cattle enzyme is more readily inhibited by diisopropyl fluorophosphate than the human. -!- Belongs to peptidase family S1.

UniProtKB Entries (1)

P08709

FA7_HUMAN

Homo sapiens

Coagulation factor VII

PDB Structure

PDB	4ISI
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Design and synthesis of bicyclic pyrazinone and pyrimidinone amides as potent TF-FVIIa inhibitors. Zhang, X., Glunz, P.W., Jiang, W., Schmitt, A., Newman, M., Barbera, F.A., Bozarth, J.M., Rendina, A.R., Wei, A., Wen, X., Rossi, K.A., Luettgen, J.M., Wong, P.C., Knabb, R.M., Wexler, R.R., Scott Priestley, E. Bioorg.Med.Chem.Lett.