CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.1600 | SIR2/SIRT2 'Small Domain' |
|
3.30.1600.10 | SIR2/SIRT2 'Small Domain' |
Domain Context
CATH Clusters
| Superfamily | SIR2/SIRT2 'Small Domain' |
| Functional Family | NAD-dependent deacetylase sir2A |
Enzyme Information
| 3.5.1.- |
In linear amides.
based on mapping to UniProt P06700
|
UniProtKB Entries (1)
| P11978 |
SIR4_YEAST
Saccharomyces cerevisiae S288C
Regulatory protein SIR4
|
PDB Structure
| PDB | 4IAO |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structural basis for allosteric stimulation of Sir2 activity by Sir4 binding
Genes Dev.
|