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1 keywords

CATH Domain 4h6jA00

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.30 2-Layer Sandwich
Topology 3.30.450 Beta-Lactamase
Homologous Superfamily 3.30.450.20 PAS domain

Domain Context

CATH Clusters

Superfamily PAS domain
Functional Family Hypoxia-inducible factor 1-alpha isoform 1

Enzyme Information

UniProtKB Entries (1)

P27540
ARNT_HUMAN
Homo sapiens
Aryl hydrocarbon receptor nuclear translocator

PDB Structure

PDB 4H6J
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Identification of Cys255 in HIF-1 alpha as a novel site for development of covalent inhibitors of HIF-1 alpha /ARNT PasB domain protein-protein interaction.
Cardoso, R., Love, R., Nilsson, C.L., Bergqvist, S., Nowlin, D., Yan, J., Liu, K.K., Zhu, J., Chen, P., Deng, Y.L., Dyson, H.J., Greig, M.J., Brooun, A.
Protein Sci.
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