CATH Domain 4fi8B00

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.60	Sandwich
	2.60.40	Immunoglobulin-like
	2.60.40.180	Transthyretin/hydroxyisourate hydrolase domain

Domain Context

CATH Clusters

Superfamily	Transthyretin/hydroxyisourate hydrolase domain
Functional Family	Transthyretin

Enzyme Information

UniProtKB Entries (1)

TTHY_HUMAN

Homo sapiens

Transthyretin

PDB Structure

PDB	4FI8
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Aromatic Sulfonyl Fluorides Covalently Kinetically Stabilize Transthyretin to Prevent Amyloidogenesis while Affording a Fluorescent Conjugate. Grimster, N.P., Connelly, S., Baranczak, A., Dong, J., Krasnova, L.B., Sharpless, K.B., Powers, E.T., Wilson, I.A., Kelly, J.W. J.Am.Chem.Soc.