CATH Domain 4faoj00

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.10	Ribbon
	2.10.60	CD59
	2.10.60.10	CD59

Domain Context

CATH Clusters

Superfamily	CD59
Functional Family	Serine/threonine-protein kinase receptor R3

Enzyme Information

2.7.11.30

Receptor protein serine/threonine kinase.

based on mapping to UniProt P37023

ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.

-!- The transforming growth factor beta (TGF-beta) family of cytokines regulates cell proliferation, differentiation, recognition and death. -!- Signaling occurs by the binding of ligand to the type II receptor, which is the constitutively active kinase. -!- Bound TGF-beta is then recognized by receptor I, which is phosphorylated and can propagate the signal to downstream substrates. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

P37023

ACVL1_HUMAN

Homo sapiens

Serine/threonine-protein kinase receptor R3

PDB Structure

PDB	4FAO
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Specificity and Structure of a High Affinity Activin Receptor-like Kinase 1 (ALK1) Signaling Complex. Townson, S.A., Martinez-Hackert, E., Greppi, C., Lowden, P., Sako, D., Liu, J., Ucran, J.A., Liharska, K., Underwood, K.W., Seehra, J., Kumar, R., Grinberg, A.V. J.Biol.Chem.