CATH Domain 4dumA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.760	RNA Cap, Translation Initiation Factor Eif4e
	3.30.760.10	RNA Cap, Translation Initiation Factor Eif4e

Domain Context

CATH Clusters

Superfamily	RNA Cap, Translation Initiation Factor Eif4e
Functional Family	Eukaryotic translation initiation factor 4E

Enzyme Information

UniProtKB Entries (1)

IF4E_HUMAN

Homo sapiens

Eukaryotic translation initiation factor 4E

PDB Structure

PDB	4DUM
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structure-Guided Design, Synthesis, and Evaluation of Guanine-Derived Inhibitors of the eIF4E mRNA-Cap Interaction. Chen, X., Kopecky, D.J., Mihalic, J., Jeffries, S., Min, X., Heath, J., Deignan, J., Lai, S., Fu, Z., Guimaraes, C., Shen, S., Li, S., Johnstone, S., Thibault, S., Xu, H., Cardozo, M., Shen, W., Walker, N., Kayser, F., Wang, Z. J.Med.Chem.