CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.60 | 4-Layer Sandwich |
|
3.60.110 | Nitrilase/N-carbamoyl-D-aminoacid amidohydrolase |
|
3.60.110.10 | Carbon-nitrogen hydrolase |
Domain Context
CATH Clusters
| Superfamily | Carbon-nitrogen hydrolase |
| Functional Family | biotinidase isoform X1 |
Enzyme Information
| 3.5.1.92 |
Pantetheine hydrolase.
based on mapping to UniProt O95497
(R)-pantetheine + H(2)O = (R)-pantothenate + 2-aminoethanethiol.
-!- Hydrolyzes only one of the amide bonds of pantetheine. -!- The substrate analogs phosphopantetheine and CoA are not substrates. -!- Recycles pantothenate (vitamin B(5)) and produces cysteamine, a potent anti-oxidant.
|
UniProtKB Entries (1)
| O95497 |
VNN1_HUMAN
Homo sapiens
Pantetheinase
|
PDB Structure
| PDB | 4CYF |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
The Structure of Vanin-1: A Key Enzyme Linking Metabolic Disease and Inflammation
Acta Crystallogr.,Sect.D
|