CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.200 | Phosphorylase Kinase; domain 1 |
|
3.30.200.20 | Phosphorylase Kinase; domain 1 |
Domain Context
CATH Clusters
| Superfamily | Phosphorylase Kinase; domain 1 |
| Functional Family | Receptor protein serine/threonine kinase |
Enzyme Information
| 2.7.11.30 |
Receptor protein serine/threonine kinase.
based on mapping to UniProt Q04771
ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.
-!- The transforming growth factor beta (TGF-beta) family of cytokines regulates cell proliferation, differentiation, recognition and death. -!- Signaling occurs by the binding of ligand to the type II receptor, which is the constitutively active kinase. -!- Bound TGF-beta is then recognized by receptor I, which is phosphorylated and can propagate the signal to downstream substrates. -!- Formerly EC 2.7.1.37.
|
UniProtKB Entries (1)
| P68106 |
FKB1B_HUMAN
Homo sapiens
Peptidyl-prolyl cis-trans isomerase FKBP1B
|
PDB Structure
| PDB | 4C02 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Crystal Structure of Human Acvr1 (Alk2) in Complex with Fkbp12.6 And Dorsomorphin
Ph D Thesis
|