CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.60 | 4-Layer Sandwich |
|
3.60.10 | Deoxyribonuclease I; Chain A |
|
3.60.10.10 | Endonuclease/exonuclease/phosphatase |
Domain Context
CATH Clusters
| Superfamily | Endonuclease/exonuclease/phosphatase |
| Functional Family | phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 |
Enzyme Information
| 3.1.3.86 |
Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase.
based on mapping to UniProt O15357
1-phosphatidyl-1D-myo-inositol 3,4,5-triphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 3,4-diphosphate + phosphate.
-!- This enzyme hydrolyzes phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P(3)) to produce PtdIns(3,4)P(2), thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. -!- The enzyme also shows activity toward PtdIns(1,3,4,5)P(4). -!- The enzyme is involved in several signal transduction pathways in the immune system leading to an adverse range of effects. -!- Formerly EC 3.1.3.n1.
|
UniProtKB Entries (1)
| O15357 |
SHIP2_HUMAN
Homo sapiens
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2
|
PDB Structure
| PDB | 4A9C |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
A Synthetic Polyphosphoinositide Headgroup Surrogate in Complex with Ship2 Provides a Rationale for Drug Discovery.
Acs Chem.Biol.
|
