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1 keywords

CATH Domain 3t0tD03

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.40 3-Layer(aba) Sandwich
Topology 3.40.1380 Pyruvate Kinase; Chain: A, domain 1
Homologous Superfamily 3.40.1380.20 Pyruvate kinase, C-terminal domain

Domain Context

CATH Clusters

Superfamily Pyruvate kinase, C-terminal domain
Functional Family Pyruvate kinase

Enzyme Information

2.7.1.40
Pyruvate kinase.
based on mapping to UniProt Q6GG09
ATP + pyruvate = ADP + phosphoenolpyruvate.
-!- UTP, GTP, CTP, ITP and dATP can also act as donors. -!- Also phosphorylates hydroxylamine and fluoride in the presence of CO(2).

UniProtKB Entries (1)

Q6GG09
KPYK_STAAR
Staphylococcus aureus subsp. aureus MRSA252
Pyruvate kinase

PDB Structure

PDB 3T0T
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Cheminformatics-driven discovery of selective, nanomolar inhibitors for staphylococcal pyruvate kinase.
Axerio-Cilies, P., See, R.H., Zoraghi, R., Worral, L., Lian, T., Stoynov, N., Jiang, J., Kaur, S., Jackson, L., Gong, H., Swayze, R., Amandoron, E., Kumar, N.S., Moreau, A., Hsing, M., Strynadka, N.C., McMaster, W.R., Finlay, B.B., Foster, L.J., Young, R.N., Reiner, N.E., Cherkasov, A.
Acs Chem.Biol.
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