CATH Domain 3sg2A01

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.238	Recoverin; domain 1
	1.10.238.10	EF-hand

Domain Context

CATH Clusters

Superfamily	EF-hand
Functional Family	Calmodulin-3

Enzyme Information

2.7.11.18

[Myosin light-chain] kinase.

based on mapping to UniProt P11799

ATP + [myosin light-chain] = ADP + [myosin light-chain] phosphate.

-!- Requires calmodulin for activity. -!- The 20 kDa light chain from smooth muscle myosin is phosphorylated more rapidly than any other acceptor, but light chains from other myosins and myosin itself can act as acceptors, more slowly. -!- Formerly EC 2.7.1.117.

UniProtKB Entries (3)

P11799	MYLK_CHICK Gallus gallus Myosin light chain kinase, smooth muscle
P0DP29	CALM1_RAT Rattus norvegicus Calmodulin-1
P42212	GFP_AEQVI Aequorea victoria Green fluorescent protein

PDB Structure

PDB	3SG2
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Optimization of a GCaMP calcium indicator for neural activity imaging. Akerboom, J., Chen, T.W., Wardill, T.J., Tian, L., Marvin, J.S., Mutlu, S., Calderon, N.C., Esposti, F., Borghuis, B.G., Sun, X.R., Gordus, A., Orger, M.B., Portugues, R., Engert, F., Macklin, J.J., Filosa, A., Aggarwal, A., Kerr, R.A., Takagi, R., Kracun, S., Shigetomi, E., Khakh, B.S., Baier, H., Lagnado, L., Wang, S.S., Bargmann, C.I., Kimmel, B.E., Jayaraman, V., Svoboda, K., Kim, D.S., Schreiter, E.R., Looger, L.L. J.Neurosci.