CATH Domain 3s24G03

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CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.40	Beta Barrel
	2.40.50	OB fold (Dihydrolipoamide Acetyltransferase, E2P)
	2.40.50.140	Nucleic acid-binding proteins

Domain Context

CATH Clusters

Superfamily	Nucleic acid-binding proteins
Functional Family	mRNA-capping enzyme

Enzyme Information

3.1.3.33	Polynucleotide 5'-phosphatase. based on mapping to UniProt O60942 A 5'-phosphopolynucleotide + H(2)O = a polynucleotide + phosphate. -!- Does not act on nucleoside monophosphates. -!- Induced in Escherichia coli by T-even phages.
2.7.7.50	mRNA guanylyltransferase. based on mapping to UniProt O60942 GTP + (5')pp-Pur-mRNA = diphosphate + G(5')ppp-Pur-mRNA. -!- Can modify also synthetic poly(A) and poly(G) to form the structures m(7)G(5')pppAn and m(7)G(5')pppGn.

UniProtKB Entries (1)

MCE1_HUMAN

Homo sapiens

MRNA-capping enzyme

PDB Structure

PDB	3S24
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structure of the guanylyltransferase domain of human mRNA capping enzyme. Chu, C., Das, K., Tyminski, J.R., Bauman, J.D., Guan, R., Qiu, W., Montelione, G.T., Arnold, E., Shatkin, A.J. Proc.Natl.Acad.Sci.USA