CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.10260 | YjeF N-terminal domain |
Domain Context
CATH Clusters
| Superfamily | YjeF N-terminal domain |
| Functional Family | NAD(P)H-hydrate epimerase |
Enzyme Information
| 5.1.99.6 |
NAD(P)H-hydrate epimerase.
based on mapping to UniProt Q8K4Z3
(1) (6R)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide = (6S)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide. (2) (6R)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide phosphate = (6S)-6-beta-hydroxy-1,4,5,6- tetrahydronicotinamide-adenine dinucleotide phosphate.
-!- The enzyme can use either (R)-NADH-hydrate or (R)-NADPH-hydrate as a substrate. -!- Its physiological role is to convert the (R) forms to the (S) forms, which could then be restored to active dinucleotides by EC 4.2.1.93.
|
UniProtKB Entries (1)
| Q8K4Z3 |
NNRE_MOUSE
Mus musculus
NAD(P)H-hydrate epimerase
|
PDB Structure
| PDB | 3ROE |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Identification of unknown protein function using metabolite cocktail screening.
Structure
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