CATH Domain 3rgqA00

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CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.190	Protein-Tyrosine Phosphatase; Chain A
	3.90.190.10	Protein tyrosine phosphatase superfamily

Domain Context

CATH Clusters

Superfamily	Protein tyrosine phosphatase superfamily
Functional Family	Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1

Enzyme Information

3.1.3.16	Protein-serine/threonine phosphatase. based on mapping to UniProt Q66GT5 [a protein]-serine/threonine phosphate + H(2)O = [a protein]- serine/threonine + phosphate. -!- A group of enzymes removing the serine- or threonine-bound phosphate group from a wide range of phosphoproteins, including a number of enzymes which have been phosphorylated under the action of a kinase (cf. EC 3.1.3.48). -!- The spleen enzyme also acts on phenolic phosphates and phosphamides (cf. EC 3.9.1.1).
3.1.3.48	Protein-tyrosine-phosphatase. based on mapping to UniProt Q66GT5 Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate. -!- Dephosphorylates O-phosphotyrosine groups in phosphoproteins, such as the products of EC 2.7.10.2.
3.1.3.27	Phosphatidylglycerophosphatase. based on mapping to UniProt Q66GT5 Phosphatidylglycerophosphate + H(2)O = phosphatidylglycerol + phosphate.

UniProtKB Entries (1)

PTPM1_MOUSE

Mus musculus

Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1

PDB Structure

PDB	3RGQ
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structural and functional analysis of PTPMT1, a phosphatase required for cardiolipin synthesis. Xiao, J., Engel, J.L., Zhang, J., Chen, M.J., Manning, G., Dixon, J.E. Proc.Natl.Acad.Sci.USA