CATH Classification

Domain Context

CATH Clusters

Superfamily Protein tyrosine phosphatase superfamily
Functional Family Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1

Enzyme Information

3.1.3.16
Protein-serine/threonine phosphatase.
based on mapping to UniProt Q66GT5
[a protein]-serine/threonine phosphate + H(2)O = [a protein]- serine/threonine + phosphate.
-!- A group of enzymes removing the serine- or threonine-bound phosphate group from a wide range of phosphoproteins, including a number of enzymes which have been phosphorylated under the action of a kinase (cf. EC 3.1.3.48). -!- The spleen enzyme also acts on phenolic phosphates and phosphamides (cf. EC 3.9.1.1).
3.1.3.48
Protein-tyrosine-phosphatase.
based on mapping to UniProt Q66GT5
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
-!- Dephosphorylates O-phosphotyrosine groups in phosphoproteins, such as the products of EC 2.7.10.2.
3.1.3.27
Phosphatidylglycerophosphatase.
based on mapping to UniProt Q66GT5
Phosphatidylglycerophosphate + H(2)O = phosphatidylglycerol + phosphate.

UniProtKB Entries (1)

Q66GT5
PTPM1_MOUSE
Mus musculus
Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1

PDB Structure

PDB 3RGQ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural and functional analysis of PTPMT1, a phosphatase required for cardiolipin synthesis.
Xiao, J., Engel, J.L., Zhang, J., Chen, M.J., Manning, G., Dixon, J.E.
Proc.Natl.Acad.Sci.USA