CATH Domain 3qcdA00

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.190	Protein-Tyrosine Phosphatase; Chain A
	3.90.190.10	Protein tyrosine phosphatase superfamily

Superfamily	Protein tyrosine phosphatase superfamily
Functional Family	receptor-type tyrosine-protein phosphatase gamma isoform X1

3.1.3.48

Protein-tyrosine-phosphatase.

based on mapping to UniProt P23470

Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.

-!- Dephosphorylates O-phosphotyrosine groups in phosphoproteins, such as the products of EC 2.7.10.2.

PTPRG_HUMAN

Homo sapiens

Receptor-type tyrosine-protein phosphatase gamma

PDB	3QCD
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Small molecule receptor protein tyrosine phosphatase [gamma](RPTP[gamma]) ligands that inhibit phosphatase activity via perturbation of the tryptophan-proline-aspartate (WPD) loop Sheriff, S., Beno, B.R., Zhai, W., Kostich, W.A., McDonnell, P.A., Kish, K., Goldfarb, V., Gao, M., Kiefer, S.E., Yanchunas, J., Huang, Y., Shi, S., Zhu, S., Dzierba, C., Bronson, J., Macor, J.E., Appiah, K.K., Westphal, R.S., O'Connell, J., Gerritz, S.W. J.Med.Chem.