CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.1620.60
Functional Family A disintegrin and metalloproteinase with thrombospondin motifs 1

Enzyme Information

3.4.24.-
Metalloendopeptidases.
based on mapping to UniProt Q9UHI8

UniProtKB Entries (1)

Q9UHI8
ATS1_HUMAN
Homo sapiens
A disintegrin and metalloproteinase with thrombospondin motifs 1

PDB Structure

PDB 3Q2G
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The design and synthesis of novel N-hydroxyformamide inhibitors of ADAM-TS4 for the treatment of osteoarthritis
De Savi, C., Pape, A., Cumming, J.G., Ting, A., Smith, P.D., Burrows, J.N., Mills, M., Davies, C., Lamont, S., Milne, D., Cook, C., Moore, P., Sawyer, Y., Gerhardt, S.
Bioorg.Med.Chem.Lett.
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