CATH Classification

Domain Context

CATH Clusters

Superfamily NADP-dependent oxidoreductase domain
Functional Family Aldo-keto reductase family 1 member C3

Enzyme Information

1.3.1.20
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase.
based on mapping to UniProt Q04828
Trans-1,2-dihydrobenzene-1,2-diol + NADP(+) = catechol + NADPH.
1.1.1.-
With NAD(+) or NADP(+) as acceptor.
based on mapping to UniProt Q04828
1.1.1.149
20-alpha-hydroxysteroid dehydrogenase.
based on mapping to UniProt Q04828
17-alpha,20-alpha-dihydroxypregn-4-en-3-one + NAD(P)(+) = 17-alpha- hydroxyprogesterone + NAD(P)H.
-!- Re-specific with respect to NAD(P)(+) (cf. EC 1.1.1.62).
1.1.1.112
Indanol dehydrogenase.
based on mapping to UniProt Q04828
Indan-1-ol + NAD(P)(+) = indanone + NAD(P)H.
-!- 3(20)-alpha-hydroxysteroids are also oxidized, more slowly.

UniProtKB Entries (1)

Q04828
AK1C1_HUMAN
Homo sapiens
Aldo-keto reductase family 1 member C1

PDB Structure

PDB 3NTY
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Probing the inhibitor selectivity pocket of human 20 alpha-hydroxysteroid dehydrogenase (AKR1C1) with X-ray crystallography and site-directed mutagenesis
El-Kabbani, O., Dhagat, U., Soda, M., Endo, S., Matsunaga, T., Hara, A.
Bioorg.Med.Chem.Lett.