CATH Domain 3mo2D00

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.170	Beta Complex
	2.170.270	Beta-clip-like
	2.170.270.10	SET domain

Domain Context

CATH Clusters

Superfamily	SET domain
Functional Family	Euchromatic histone-lysine N-methyltransferase 2

Enzyme Information

2.1.1.-	Methyltransferases. based on mapping to UniProt Q9H9B1
2.1.1.43	Histone-lysine N-methyltransferase. based on mapping to UniProt Q9H9B1 S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

UniProtKB Entries (1)

EHMT1_HUMAN

Homo sapiens

Histone-lysine N-methyltransferase EHMT1

PDB Structure

PDB	3MO2
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Adding a lysine mimic in the design of potent inhibitors of histone lysine methyltransferases. Chang, Y., Ganesh, T., Horton, J.R., Spannhoff, A., Liu, J., Sun, A., Zhang, X., Bedford, M.T., Shinkai, Y., Snyder, J.P., Cheng, X. J.Mol.Biol.