CATH Classification
Level | CATH Code | Description |
---|---|---|
2 | Mainly Beta | |
2.60 | Sandwich | |
2.60.40 | Immunoglobulin-like | |
2.60.40.150 | C2 domain |
Domain Context
CATH Clusters
Superfamily | C2 domain |
Functional Family | Putative E3 ubiquitin-protein ligase NEDD4-like |
Enzyme Information
2.3.2.26 |
HECT-type E3 ubiquitin transferase.
based on mapping to UniProt P46935
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)- ubiquitinyl-[acceptor protein]-L-lysine.
-!- In the first step the enzyme transfers ubiquitin from the E2 ubiquitin-conjugating enzyme (EC 2.3.2.23) to a cysteine residue in its HECT domain (which is located in the C-terminal region), forming a thioester bond. -!- In a subsequent step the enzyme transfers the ubiquitin to an acceptor protein, resulting in the formation of an isopeptide bond between the C-terminal glycine residue of ubiquitin and the epsilon- amino group of an L-lysine residue of the acceptor protein. -!- Cf. EC 2.3.2.27 and EC 2.3.2.31.
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UniProtKB Entries (1)
P46935 |
NEDD4_MOUSE
Mus musculus
E3 ubiquitin-protein ligase NEDD4
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PDB Structure
PDB | 3M7F |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Structural Basis for the Interaction between the Growth Factor-binding Protein GRB10 and the E3 Ubiquitin Ligase NEDD4.
J.Biol.Chem.
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